M. Robinson

Simulating clinical trials for model-informed precision dosing: Using warfarin treatment as a use case

This paper develops a framework to simulate clinical trials for model-informed precision dosing, using warfarin treatment to compare three methods: neural network regression, deep reinforcement learning, and PKPD modelling.

Global and cell type-specific immunological hallmarks of severe dengue progression

This study identifies DENV target cells and immunological changes in severe dengue progression using single-cell RNA-Seq and functional assays in children.

CTLA-4 regulates PD-L1-PD-1 interactions via transendocytosis of CD80

The paper investigates how CTLA-4 regulates PD-L1-PD-1 interactions through CD80 transendocytosis, showing that CD80 removal enables PD-L1 recovery and that CTLA-4's cytoplasmic domain is essential for this process.

Deep Learning-based Automated Rare Sperm Identification from Testes Biopsies

The paper develops a CNN to detect rare sperm in testis biopsies, achieving an 85.2% F1 score, which could improve IVF-ICSI success rates for NOA patients.

Metabotropic group II glutamate receptors mediate cue-triggered increases in incentive motivation for reward

This study investigates how mGlu2/3 receptor activity mediates cue-triggered increases in reward motivation in male and female rats using Pavlovian-to-instrumental transfer procedures.

New water and air pollution sensors added to the Sonic Kayak citizen science system for low cost environmental mapping

The paper introduces two new sensors for turbidity and air particulate pollution to the Sonic Kayak system, enabling low-cost environmental data collection and mapping.

Characterization of SOX2, OCT4 and NANOG in ovarian cancer tumor-initiating cells

This study evaluates SOX2, OCT4, and NANOG expression in ovarian cancer cell lines under 2-D and 3-D culture conditions, finding SOX2 is more strongly associated with tumor-initiating cells and chemotherapy resistance.

Highly multiplexed oligonucleotide probe-ligation testing enables efficient extraction-free SARS-CoV-2 detection and viral genotyping

This paper introduces cRASL-seq, a method for sensitive and high-throughput SARS-CoV-2 detection and genotyping without nucleic acid extraction or reverse transcription.

Melatonin alters fluid phase co-existence in POPC/DPPC/cholesterol membranes

This study investigates how melatonin affects phase separation in ternary lipid membranes, suggesting a potential mechanism for its neuroprotective effects against amyloid-beta toxicity.

Functional characterization and lineage analysis of broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics

The paper identifies two broadly neutralizing antibodies against dengue virus through single B cell transcriptomics and characterizes their epitopes and evolutionary pathways.

Active Receptor Tyrosine Kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish

This study identifies that RTKs EGFR and KDR/VEGFR2, not Brachyury, can induce chordoma in zebrafish by disrupting notochord differentiation through RTK/Ras signaling.

Virus-inclusive single cell RNA sequencing reveals molecular signature predictive of progression to severe dengue infection

This study uses single-cell RNA sequencing to identify molecular signatures predictive of severe dengue infection by analyzing PBMCs from dengue patients and healthy controls.