Direct focus sensing and shaping for high-resolution multi-photon imaging in deep tissue
J. Qu, Z. QIN, Z. SHE, C. CHEN, W. WU, J. LAU, N. Ip
This paper develops an adaptive optics three-photon microscope for high-resolution imaging in deep brain tissue, achieving near-diffraction-limited performance and enabling functional calcium imaging and microsurgery through the intact skull.
bioRxiv · Aug 4, 2021 · PreprintBioengineering