J. Lau

A new pathway in central metabolism mediates nutrient control of development and antibiotic production by Streptomyces

This paper identifies a novel aminosugar metabolic pathway in Streptomyces that regulates development and antibiotic production through GlcNAc sensing.

Mouse models for pancreatic ductal adenocarcinoma are affected by the cre-driver used to promote KRASG12D activation.

This study compares mouse models of pancreatic ductal adenocarcinoma driven by different cre-recombinase systems, finding differences in tumor development and inflammation.

Distinct human stem cell subpopulations drive adipogenesis and fibrosis in musculoskeletal injury

The paper identifies distinct FAP subpopulations in human musculoskeletal injuries that drive adipogenesis and fibrosis, showing that DLK1 downregulation promotes degeneration.

Direct focus sensing and shaping for high-resolution multi-photon imaging in deep tissue

This paper develops an adaptive optics three-photon microscope for high-resolution imaging in deep brain tissue, achieving near-diffraction-limited performance and enabling functional calcium imaging and microsurgery through the intact skull.

Agonistic CD40 antibody therapy induces tertiary lymphoid structures but impairs the response to immune checkpoint blockade in glioma

This study shows that agonistic CD40 antibody therapy in glioma models causes T cell dysfunction and reduces response to checkpoint inhibitors, but also promotes tertiary lymphoid structures associated with improved T cell infiltration.