BiochemistrybioRxiv
Structural basis for the RNA-guided ribonuclease activity of CRISPR-Cas13d
C. Zhang, S. Konermann, N. J. Brideau…·D. Lyumkis
The paper determines the structural basis of CRISPR-Cas13d's RNA-guided ribonuclease activity through cryo-EM and biochemical analysis, revealing its molecular architecture and activation mechanisms.
DOI 10.1016/j.cell.2018.09.001