BiochemistrybioRxivPreprint
The urea cycle is transcriptionally controlled by hypoxia-inducible factors
C. Singh, A. Benos, A. Grenell…·J. Sears
The paper shows that HIFs regulate urea cycle genes CPS1 and ARG1, leading to increased urea cycle activity in the liver under hypoxia.
DOI 10.1101/2021.01.25.428152