C. Singh

Microglial depletion decreases Müller cell maturation and inner retinal vascular density

This study shows that microglia depletion reduces Müller cell maturation and inner retinal vascular density in mice.

Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells

This study shows that TIMP3 mutations in RPE cells increase glycolytic activity and disrupt glutamine metabolism, linking these changes to Sorsbys Fundus Dystrophy.

Systems levels analysis of lipid metabolism in oxygen-induced retinopathy

This study investigates lipid metabolism in oxygen-induced retinopathy, showing that medium-chain fatty acid octanoate can replenish the TCA cycle in hyperoxic conditions.

Low intensity mechanical signals promote proliferation in a cell-specific manner: Tailoring a non-drug strategy to enhance biomanufacturing yields.

The paper tests low-intensity vibration to enhance cell proliferation in biomanufacturing, showing it can be tailored to different cell types to improve yields.

The urea cycle is transcriptionally controlled by hypoxia-inducible factors

The paper shows that HIFs regulate urea cycle genes CPS1 and ARG1, leading to increased urea cycle activity in the liver under hypoxia.

Hyperoxia inhibits proliferation of retinal endothelial cells in Myc dependent manner

The paper shows hyperoxia inhibits retinal endothelial cell proliferation via Myc dependency, contributing to oxygen-induced retinopathy.

Correlating the structure and activity of Y. pestis Ail in a bacterial cell envelope

This study uses an E. coli model system to investigate the structure and function of Y. pestis Ail in a bacterial cell envelope, revealing its role in virulence and interactions with human serum components.

Effect of dioxins in milk on 3D-cultured primary buffalo granulosa cells, a pilot study for a prospective RT-LAMP colour reaction for dioxin toxicity

The paper tests a 3D-cultured buffalo granulosa cell-based RT-LAMP colour reaction to detect dioxin toxicity in milk, finding AHR expression as a potential marker.