Author

N. L. Samara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Lam· 1 shared A. Werner· 1 shared B. Hassan· 1 shared B. Kwong· 1 shared B. Terrier· 1 shared C. J. Ballard· 1 shared D. B. Beck· 1 shared D. C. Zeldin· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperBiochemistry

A. Lam

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Author profile →

3 papers

Recent·Most cited

A Toxoplasma gondii O-glycosyltransferase that modulates bradyzoite cyst wall rigidity is structurally and functionally distinct from host homologues

P. Kumar, T. Tomita, T. A. Gerken, C. J. Ballard, Y. S. Lee, L. M. Weiss, N. L. Samara

This study identifies and characterizes a Toxoplasma gondii O-glycosyltransferase, T.gondii-GalNAc-T3, revealing structural and functional differences from host homologues and identifying potential drug targets for parasitic diseases.

bioRxiv · Oct 26, 2023 · PreprintBiochemistry

Shared and Distinct Mechanisms of UBA1 Inactivation Across Different Diseases

J. C. Collins, S. J. Magaziner, M. English, B. Hassan, X. Chen, N. Balanda, M. Anderson, A. Lam, S. Fernandez-Pol, B. Kwong, P. L. Greenberg, B. Terrier, M. E. Likhite, O. Kosmider, Y. Wang, , A. Werner

This study identifies shared and distinct mechanisms of UBA1 inactivation in VEXAS syndrome and related diseases, revealing how different mutations affect ubiquitin transfer to E2 enzymes.

bioRxiv · Oct 10, 2023Biochemistry

Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation

L. Zhang, M. Mann, Z. Syed, H. M. Reynolds, E. Tian, N. L. Samara, D. C. Zeldin, L. A. Tabak, K. G. Ten Hagen

This study shows that O-glycosylation near the furin cleavage site of SARS-CoV-2 spike protein reduces furin cleavage and is mediated by GALNT enzymes and a proline at position 681.

bioRxiv · Feb 5, 2021Biochemistry