Shared and Distinct Mechanisms of UBA1 Inactivation Across Different Diseases
J. C. Collins, S. J. Magaziner, M. English, B. Hassan, X. Chen, N. Balanda, M. Anderson, A. Lam, S. Fernandez-Pol, B. Kwong, P. L. Greenberg, B. Terrier, M. E. Likhite, O. Kosmider, Y. Wang, , A. Werner
This study identifies shared and distinct mechanisms of UBA1 inactivation in VEXAS syndrome and related diseases, revealing how different mutations affect ubiquitin transfer to E2 enzymes.
bioRxiv · Oct 10, 2023Biochemistry