A. Werner

STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NFkB signaling

This study shows STING activates NFkB signaling via HOIP-mediated M1 ubiquitin chains on Golgi membranes, independent of LC3B lipidation.

Shared and Distinct Mechanisms of UBA1 Inactivation Across Different Diseases

This study identifies shared and distinct mechanisms of UBA1 inactivation in VEXAS syndrome and related diseases, revealing how different mutations affect ubiquitin transfer to E2 enzymes.

Four novel Caudoviricetes bacteriophages isolated from Baltic Sea water infect colonizers of Aurelia aurita

The paper isolates and characterizes four novel bacteriophages from Baltic Sea water that infect bacteria associated with the moon jellyfish Aurelia aurita.

Biodiversity and local interaction complexity promote sustainable fisheries in large food webs

This study uses a synthetic model to show that fishing impacts on species depend on trophic level, local interaction complexity, and biodiversity, suggesting sustainable fisheries should target low trophic level species in high biodiversity ecosystems.

TNIP1 inhibits Mitophagy via interaction with FIP200 and TAX1BP1

This study identifies TNIP1 as a negative regulator of mitophagy that interacts with FIP200 and TAX1BP1 to modulate autophagosome biogenesis.

Pangenome evolution in environmentally transmitted symbionts of deep-sea mussels is governed by vertical inheritance

This study examines pangenome evolution in symbionts of deep-sea mussels, finding that vertical inheritance, not horizontal gene transfer, drives genetic diversity in environmentally acquired bacterial symbionts.

L-citrulline ameliorates pathophysiology in a rat model of superimposed preeclampsia

This study shows L-citrulline reduces hypertension, improves placental function, and fetal growth in a rat model of preeclampsia.

Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection

This paper describes a monoclonal antibody, DZIF-10c, that effectively neutralizes SARS-CoV-2 and its variants when administered intranasally to mice, offering potential for topical treatment.

Evaluation of mRNA-1273 against SARS-CoV-2 B.1.351 Infection in Nonhuman Primates

This study evaluates mRNA-1273 vaccine efficacy against SARS-CoV-2 B.1.351 in nonhuman primates, finding that two doses significantly reduce viral replication in the airways.

Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA SARS 2 S in preclinical vaccination

This paper describes the preclinical evaluation of MVA-SARS-2-S, a vector vaccine against SARS-CoV-2, showing it induces immune responses and protects mice from infection.

Human antigen-specific memory natural killer cell responses develop against HIV-1 and influenza virus and are dependent on MHC-E restriction

This study shows human NK cells develop antigen-specific memory against HIV-1 and influenza via MHC-E restriction, validated through single-cell cloning and biomarker analysis.

A Platform Incorporating Trimeric Antigens into Self-Assembling Nanoparticles Reveals SARS-CoV-2-Spike Nanoparticles to Elicit Substantially Higher Neutralizing Responses than Spike Alone

This paper develops a nanoparticle platform for displaying trimeric antigens, showing that SARS-CoV-2 spike-LuS nanoparticles induce 25-fold higher neutralizing responses than spike alone.