Atypical Chemokine Receptor 1 (Ackr1)-deficient Mice Resist Lethal SARS-CoV-2 Challenge
S. Majumdar, J. D. Weaver, S. M. Pontejo, M. Minai, S. Georgia-Clark, J.-L. Gao, X. Lu, H. Zhang, N. Lackemeyer, T. Burdette, R. Johnson, B. L. Kelsall, J. M. Farber, D. A. Alves, P. M. Murphy
This study shows that Ackr1-deficient mice have lower mortality from SARS-CoV-2 infection, suggesting ACKR1 may contribute to COVID-19 immunopathology and could be a drug target.
bioRxiv · Jun 5, 2023 · PreprintImmunology