S. Majumdar

This paper identifies a negative allosteric modulator of the μ-opioid receptor that blocks agonist activity and enhances naloxone efficacy, offering potential for safer opioid overdose reversal.

This study shows that Ackr1-deficient mice have lower mortality from SARS-CoV-2 infection, suggesting ACKR1 may contribute to COVID-19 immunopathology and could be a drug target.

This study determines the structure of the hibernating ribosome in Borrelia burgdorferi using cryo-EM, revealing new structural features and insights into antibiotic binding.

This study shows that the mycobacterial ribosomal protein bS22 modulates aminoglycoside binding to the 16S rRNA helix-44 site, influencing antibiotic resistance.

The paper identifies a new potential drug-binding site in alanine racemase by combining computational analysis and experimental validation, suggesting it for allosteric antibiotic development.

The paper uses RNASeq to identify differentially expressed genes in oral cancer, analyzes their functional enrichment, and identifies hub genes as potential biomarkers for margin clearance.

This study shows that reduced HOXA10 expression in mice leads to endometrial hyperplasia and cancer progression with age.

This study compares the structural and signaling differences between two μOR agonists, lofentanil and mitragynine pseudoindoxyl, revealing how their distinct binding modes lead to different G protein and β-arrestin activation profiles.

This paper introduces a new class of iboga alkaloids, oxa-iboga, which show therapeutic efficacy in opioid use disorder without cardiac risks, as demonstrated in rat models.

The paper develops a novel mitragynine analog with reduced mu-opioid receptor efficacy and adverse effects, showing antinociception without respiratory depression or hyperlocomotion.

The paper investigates how actin filament alignment affects mechanical hysteresis in cross-linked networks by varying cross-linker concentration and properties.

This paper identifies an antibody epitope and a risk score to predict severe COVID-19 outcomes with high specificity.

This study investigates the oligomerisation of hTHAP9 and DmTNP, showing DNA and amino-terminal domains are involved, with Hcf-1 and other THAP proteins as potential interaction partners.

This study uses directed evolution to reengineer the BoNT/A protease to target SNAP23, improving its cleavage specificity and catalytic efficiency for therapeutic applications.

This study uses self-organizing maps of single-cell Raman spectra to analyze how PMA stimulation and adhesion factors affect THP-1 cell differentiation into macrophage-like cells.

This study evaluates the interaction between SARS-CoV-2 spike protein and ACE2 receptors across species to predict viral entry probabilities in different animals.

This study identifies a sequential therapy strategy using HDAC inhibitors to reverse chemotherapy-induced resistance in ER+ breast cancer by targeting cancer stem cell-like traits.

This study shows that the Leishmania Donovani protein KMP-11 induces membrane phase transition in macrophages, facilitating infection by altering membrane tension and lipid raft structure.

The paper develops a cell-based assay to study agonist-selective recruitment of engineered protein probes and GRK2 by opioid receptors in living cells, showing differential recruitment by distinct opioid ligands.

This paper develops a method using vortex fluidics to rescue DNA from formalin-fixed specimens, achieving PCR-amplifiable DNA recovery from American lobster tissue.