N. LeBrasseur

This study identifies p21+ senescent-like cells, including osteochondroprogenitors and neutrophils, as key regulators of fracture repair, showing their distinct roles from age-related p16+ senescent cells.

The paper examines p21Cip1 and p16Ink4a expression in senescent cells across tissues, revealing heterogeneity and tissue-specific SASP profiles.

This study shows zoledronate kills senescent cells in vitro and reduces SASP markers in vivo, suggesting potential senolytic and senomorphic effects.

This paper introduces a novel gene set, SenMayo, to identify senescent cells and predict senescence-associated pathways across tissues and species.

This study shows that telomere damage independent of length causes cardiomyocyte senescence, leading to cardiac dysfunction, and that clearing senescent cells improves cardiac health.