D. Monroe

Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair

This study identifies p21+ senescent-like cells, including osteochondroprogenitors and neutrophils, as key regulators of fracture repair, showing their distinct roles from age-related p16+ senescent cells.

Distinct secretomes in p16- and p21- positive senescent cells across tissues

The paper examines p21Cip1 and p16Ink4a expression in senescent cells across tissues, revealing heterogeneity and tissue-specific SASP profiles.

In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers

This study shows zoledronate kills senescent cells in vitro and reduces SASP markers in vivo, suggesting potential senolytic and senomorphic effects.

Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

The paper uses CyTOF to identify senescent mesenchymal cells in aged mice, finding CD24+ osteolineage cells as targets for senolytic therapy.

Identification of a suitable endogenous control miRNA in bone aging and senescence

The paper identifies Let-7f as a stable endogenous control miRNA for normalizing miRNA expression in bone aging and senescence, showing improved accuracy compared to U6.

A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues

This paper introduces a novel gene set, SenMayo, to identify senescent cells and predict senescence-associated pathways across tissues and species.

Modulation of fracture healing by the transient accumulation of senescent cells

This study shows that senescent cells temporarily accumulate during murine fracture healing, and their removal with senolytics accelerates healing, unlike in skin wounds.