N. M. Pearce

The paper shows that properly treated crystallographic fragment-screening data do not suffer from the criticisms raised by Jaskolski et al.

This paper introduces a method to decompose structural disorder into hierarchical contributions, enabling better understanding of macromolecular dynamics from B-factors and alternative conformations.

The paper presents crystal and cryo-EM structures of CD9 with nanobodies and EWI-F, revealing a tetrameric arrangement that provides a model for tetraspanin-enriched microdomain assembly.

The paper identifies a new allosteric site in PTP1B using multitemperature crystallography and fragment screening, showing covalent tethering can inhibit enzyme activity.

The paper describes a high-throughput method for crystal soaking using acoustic droplet ejection, showing it is gentle, fast, and effective for generating protein-ligand complexes.