Author

P. Gros

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Assay:structural biology· 2 Assay:cryo-EM· 1

Frequent Co-Authors

M. Ruyken· 2 shared N. M. Pearce· 2 shared S. H. M. Rooijakkers· 2 shared W. Oosterheert· 2 shared A. Kuipers· 1 shared A. Malik· 1 shared A. Sendoel· 1 shared B. W. Bardoel· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

M. Ruyken

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies

E. M. Struijf, K. I. De la O Becerra, M. Ruyken, F. van Oosterom, D. Y. Siere, D. A. C. Heesterbeek, E. Dolk, R. Heukers, B. W. Bardoel, P. Gros, S. H. M. Rooijakkers

This study identifies and characterizes two high-affinity anti-C5 nanobodies that inhibit C5 cleavage and recognize distinct epitopes, including a variant not targeted by Eculizumab.

bioRxiv · Feb 22, 2023Immunology

In vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer

S. Martinez, R. Weber, T. Woo, A. Malik, M. Geuenich, G. H. Jang, D. Dervovic, K. Al-Zahrani, R. Tsai, N. Fodil, P. Gros, S. S. Sidhu, S. Gallinger, G. Neely, K. Campbell, , D. Schramek

This study uses in vivo CRISPR screens to identify USP15 and SCAF1 as novel tumor suppressors in pancreatic cancer, with potential therapeutic implications.

bioRxiv · Mar 13, 2022Cancer Biology

A method for intuitively extracting macromolecular dynamics from structural disorder

N. M. Pearce, P. Gros

This paper introduces a method to decompose structural disorder into hierarchical contributions, enabling better understanding of macromolecular dynamics from B-factors and alternative conformations.

bioRxiv · Mar 22, 2021Biochemistry

C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases

S. A. Zwarthoff, K. Widmer, A. Kuipers, J. Strasser, M. Ruyken, P. Aerts, C. J. C. de Haas, D. Ugurlar, G. Vidarsson, J. van Strijp, P. Gros, P. Parren, K. P. M. van Kessel, J. Preiner, F. J. Beurskens, , S. H. M. Rooijakkers

This study shows that C1r2s2 proteases stabilize C1q binding to surface-bound IgG, with subclass-specific effects and improved phagocytosis with hexamer-enhanced IgGs.

bioRxiv · Feb 8, 2021Immunology

Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F

W. Oosterheert, K. T. Xenaki, V. Neviani, W. Pos, S. Doulkeridou, J. Manshande, N. M. Pearce, L. M. J. Kroon-Batenburg, M. Lutz, P. M. P. van Bergen en Henegouwen, P. Gros

The paper presents crystal and cryo-EM structures of CD9 with nanobodies and EWI-F, revealing a tetrameric arrangement that provides a model for tetraspanin-enriched microdomain assembly.

Life Science Alliance · Nov 1, 2020Peer-reviewedBiophysics

Structural basis for targeting human cancer antigen STEAP1 with antibodies

W. Oosterheert, P. Gros

The paper presents a cryo-EM structure of STEAP1 bound to antibodies and shows it functions as a ferric reductase in hetero-trimers, providing insights for cancer therapy.

Journal of Biological Chemistry · Jul 1, 2020Peer-reviewedBiophysics