Pharmacology & ToxicologybioRxiv
A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects
S. Chakraborty, J. F. Diberto, A. Faouzi…·s. majumdar
The paper develops a novel mitragynine analog with reduced mu-opioid receptor efficacy and adverse effects, showing antinociception without respiratory depression or hyperlocomotion.
DOI 10.1021/acs.jmedchem.1c01273