Author

D. Provasi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

M. Filizola· 3 shared A. Faouzi· 1 shared A. M. Gutridge· 1 shared B. L. Roth· 1 shared D. Meral· 1 shared D. Sames· 1 shared E. B. Margolis· 1 shared J. A. Javitch· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiophysics

M. Filizola

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects

S. Chakraborty, J. F. Diberto, A. Faouzi, S. M. bernhard, A. M. Gutridge, S. Ramsey, Y. Zhou, D. Provasi, N. Nuthikattu, R. Jilakara, M. Nelson, W. B. Asher, S. O. Eans, L. L. Wilson, S. M. Chintala, , s. majumdar

The paper develops a novel mitragynine analog with reduced mu-opioid receptor efficacy and adverse effects, showing antinociception without respiratory depression or hyperlocomotion.

bioRxiv · Apr 22, 2021Pharmacology & Toxicology

Mechanism of μ-Opioid Receptor-Magnesium Interaction and Positive Allosteric Modulation.

X. Hu, D. Provasi, M. Filizola

This study uses molecular dynamics simulations to investigate how magnesium ions bind to and modulate the μ-opioid receptor, revealing their role in stabilizing the activated state and enhancing opioid efficacy.

Biophysical Journal · Feb 1, 2020Peer-reviewedBiophysics

An Efficient Strategy to Estimate Thermodynamics and Kinetics of G Protein-Coupled Receptor Activation Using Metadynamics and Maximum Caliber.

D. Meral, D. Provasi, M. Filizola

This paper develops a method combining metadynamics and maximum caliber to estimate thermodynamic and kinetic properties of GPCR activation efficiently.

bioRxiv · Jul 12, 2018Biophysics