N. Pavin

Model for chromosome congression based on motor proteins in microtubule overlaps

The paper introduces a physical model to explain chromosome congression by analyzing forces from motor proteins and passive crosslinkers in the mitotic spindle.

Mechanical Dissociation of Tissues for Single Cell Analysis Using a Simple Motorized Device

This paper introduces a low-cost motorized device for automated tissue dissociation, improving reproducibility and reducing time compared to manual methods.

Coordinated poleward flux of sister kinetochore fibers drives chromosome alignment

The paper introduces a flux-driven model for chromosome alignment, showing that length-dependent kinetochore fiber flux, regulated by Kif18A, Kif4A, and NuMA, promotes proper chromosome positioning.

Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes

This paper introduces a mathematical model to explain how proliferative advantage of specific aneuploid cells drives tumor karyotype evolution through chromosome gains and losses.

Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly

The paper shows that kinetochores and chromosomes drive the formation of microtubule bundles during spindle assembly through a network-to-bundles transition.

Measurement of curvature and twist of microtubule bundles in the mitotic spindle

This paper introduces a method to measure curvature and twist of microtubule bundles in mitotic spindles using confocal microscopy and geometric analysis.

Chromosome loss rate in cells of different ploidy can be explained by spindle self-organization

The paper develops a mathematical model to explain how chromosome loss rates vary with ploidy by considering spindle dynamics and mitotic arrest duration.

Pivoting of microtubules driven by minus end directed motors leads to their alignment to form an interpolar bundle

The paper shows microtubules from opposite poles align into antiparallel bundles through random rotation and minus end directed motor activity.

Pivot-and-bond model explains microtubule bundle formation

The paper shows that random angular movement and cross-linking forces explain microtubule bundle formation during mitosis.

The mitotic spindle is chiral due to torques generated by motor proteins

The paper shows that the mitotic spindle is chiral due to torques from motor proteins, demonstrated through microscopy and a theoretical model.