I. M. Tolic

This study shows CENP-E initiates chromosome congression by stabilizing end-on attachments and counteracting Aurora B phosphorylation, promoting biorientation-dependent movement.

The paper investigates mitotic strategies in Ichthyosporea, showing divergence towards fungal-like closed or animal-like open mitosis, with multinucleated life cycles favoring closed mitosis.

The paper introduces a flux-driven model for chromosome alignment, showing that length-dependent kinetochore fiber flux, regulated by Kif18A, Kif4A, and NuMA, promotes proper chromosome positioning.

This paper introduces a mathematical model to explain how proliferative advantage of specific aneuploid cells drives tumor karyotype evolution through chromosome gains and losses.

The paper shows that kinetochores and chromosomes drive the formation of microtubule bundles during spindle assembly through a network-to-bundles transition.

The paper identifies unique mitotic tubulins in Naegleria amoebae and characterizes their spindle structure, suggesting ancestral features of mitosis.

This paper introduces a method to measure curvature and twist of microtubule bundles in mitotic spindles using confocal microscopy and geometric analysis.

This study measures spindle chirality and shows it is regulated by microtubule motors and augmin, with implications for mechanical response to forces during mitosis.

This paper shows that augmin promotes proper microtubule arrangement to prevent merotelic attachments during mitosis.

This study uses optogenetic removal of PRC1 to show that bridging fibers promote chromosome alignment through overlap length-dependent forces.

The paper identifies KIF4A and EG5 as essential for spindle elongation through microtubule sliding in human cells, showing two independent sliding modules drive this process.

The paper shows microtubules from opposite poles align into antiparallel bundles through random rotation and minus end directed motor activity.

The paper shows that the mitotic spindle is chiral due to torques from motor proteins, demonstrated through microscopy and a theoretical model.