Enhanced Solid Tumor Recognition and T cell Stemness with SynNotch CAR Circuits
A. Hyrenius-Wittsten, Y. Su, M. Park, J. M. Garcia, N. Perry, G. Montgomery, B. Liu, K. T. Roybal
This study identifies ALPPL2 as a tumor-specific antigen and demonstrates that synNotch CAR T cells targeting it improve tumor control by reducing T cell exhaustion.
bioRxiv · Jan 6, 2021 · PreprintImmunology