Integrated Multi-omics Analyses of NFKB1 patients B cells points towards an up regula-tion of NF-κB network inhibitors
N. Camacho-Ordonez, N. Ramirez, S. Posadas-Cantera, A. Caballero-Oyteza, M. Fliegauf, F. Zhao, M. Guarini, V. Gernedl, M. Pecoroaro, K. Warnatz, C. Bock, E. Ballestar, R. Geiger, M. Proietti, B. Grimbacher
This study identifies epigenetic and gene expression changes in B cells from NFKB1 mutation carriers, highlighting dysregulation of NF-κB network inhibitors and potential therapeutic targets.
bioRxiv · Nov 22, 2022 · PreprintImmunology