Cancer BiologybioRxivPreprint
PIK3CA in KrasG12D/Trp53R172H Tumor Cells Promotes Immune Evasion by Limiting Infiltration of T Cells in a Model of Pancreatic Cancer
N. Sivaram, P. A. McLaughlin, H. V. Han…·R. Z. Lin
This study shows that PIK3CA-AKT signaling in pancreatic cancer cells limits T cell infiltration and tumor clearance by reducing MHC Class I and CD80 expression, suggesting it as a target for immunotherapy.
DOI 10.1101/521831