K. Pham

An unexpected histone chaperone function for the MIER1 histone deacetylase complex

The paper identifies an unexpected histone chaperone function for the MIER1 histone deacetylase complex, showing its ability to bind histone dimers and octamers and associate with nucleosomes.

Electronic cigarettes induce mitochondrial DNA damage and trigger toll-like receptor 9-mediated atherosclerosis

This study shows that e-cigarette vapor causes mitochondrial DNA damage, which activates TLR9 and promotes atherosclerosis in mice.

Post-transcriptional splicing can occur in a slow-moving zone around the gene

The paper uses imaging techniques to show that splicing occurs in a slow-moving zone near the transcription site, suggesting a model where splicing is post-transcriptional but occurs close to transcription.

Developing T cells form an immunological synapse for passage through the β-selection checkpoint

The paper shows developing T cells form an immunological synapse to pass the β-selection checkpoint, integrating signals from Notch, CXCR4, and MHC.

A new role for Notch in control of polarity and asymmetric cell division of developing T cells

This study shows Notch signaling directly controls asymmetric cell division in developing T cells by regulating Notch1 and fate determinants distribution.

PIK3CA in KrasG12D/Trp53R172H Tumor Cells Promotes Immune Evasion by Limiting Infiltration of T Cells in a Model of Pancreatic Cancer

This study shows that PIK3CA-AKT signaling in pancreatic cancer cells limits T cell infiltration and tumor clearance by reducing MHC Class I and CD80 expression, suggesting it as a target for immunotherapy.