Cell BiologybioRxivPreprint
Human Beta Cell Mass Expansion In Vivo With A Harmine and Exendin-4 Combination: Quantification and Visualization By iDISCO+ 3D Imaging
C. Rosselot, A. Alvarsson, P. Wang…·A. Garcia-Ocana
This study shows a combination of DYRK1A inhibitor and GLP1R agonist increases human beta cell mass in vivo by 400-700% in mice, using iDISCO+ 3D imaging for quantification.