K. Kumar

Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3

The paper identifies iDegs, which enhance IDO1 degradation via the native CRL2KLHDC3 pathway, reducing kynurenine formation and offering new therapeutic potential for cancer.

White adipose tissue remodeling in Little Brown Myotis (Myotis lucifugus) with white-nose syndrome

This study compares white adipose tissue lipid composition between WNS-susceptible and resistant bat species, finding differential lipid profiles and WAT remodeling in infected susceptible bats.

Apoptotic proteins in Leishmania donovani: In silico screening, modelling, and validation by knock-out and gene expression analysis

The paper identifies and validates apoptotic proteins in Leishmania donovani using computational screening, molecular docking, and CRISPR-Cas9 knock-out experiments, showing their role in parasite apoptosis.

Exploring variations in lipids among drug-resistant and sensitive Mycobacterium tuberculosis by Thin layer chromatography and mass spectrometry

The paper analyzes lipid composition differences between drug-resistant and sensitive Mycobacterium tuberculosis isolates using thin layer chromatography and mass spectrometry, finding increased phospholipids and alpha-mycolic acids in resistant strains.

Characterization, structure and inhibition of the human succinyl-CoA:glutarate-CoA transferase, a genetic modifier of glutaric aciduria type 1

The paper characterizes the human SUGCT enzyme, determines its structure, and identifies inhibitors that may lead to new treatments for glutaric aciduria type 1.

Ultrasound-Assisted Hydrolysis of Food Waste using Glucoamylase: Statistical Optimization and Mechanistic Analysis with Molecular Simulations

This paper optimizes food waste hydrolysis using glucoamylase and sonication, showing improved sugar yield and reaction kinetics through structural and computational analysis.

Acetone-Butanol-Ethanol (ABE) fermentation with Clostridial Co-cultures for Enhanced Biobutanol Production

This study optimizes ABE fermentation using Clostridial co-cultures to enhance biobutanol production through statistical analysis of process parameters.

Influence of amino acid substitutions in capsid proteins of coxsackievirus B5 on free chlorine and thermal inactivation

This study investigates how amino acid substitutions in coxsackievirus B5 capsid proteins affect sensitivity to free chlorine and heat, finding that capsid changes have a minor role in chlorine sensitivity but reduce heat sensitivity in specific mutants.

Cheminformatics analysis of multi-target structure-activity landscape of environmental chemicals binding to human endocrine receptors

This study analyzes the structure-activity landscape of environmental chemicals binding to multiple human endocrine receptors to improve toxicity prediction models.

Polyimide-Based Flexible Multi-Electrode Arrays for Epilepsy: Synthesis, Microfabrication, and In-Vivo Validation In A Rodent Model of Epilepsy

This study develops biocompatible polyimide-based flexible electrodes for epilepsy monitoring in a rodent model, demonstrating mechanical flexibility, long-term stability, and safety.

Analysis of structure-activity and structure-mechanism relationships among thyroid stimulating hormone receptor binding chemicals by leveraging ToxCast library

The paper analyzes structure-activity and structure-mechanism relationships of TSHR-binding chemicals using ToxCast data to improve predictive toxicity models.

SWI/SNF complex-mediated chromatin remodelling in Candida glabrata is vital for immune evasion

This study shows that chromatin remodelling by the SWI/SNF complex in Candida glabrata affects immune evasion by modulating gene expression in macrophages.

Comparative transcriptome analysis in contrasting finger millet (Eleusine coracana (L.) Gaertn) genotypes for heat stress

This study compares transcriptome responses to heat stress in two finger millet genotypes, identifying differentially expressed genes and pathways associated with heat tolerance.

Transcriptome analysis reveals robust transcriptional reprogramming during early stages of Cicer-Ascochyta interaction

This study compares transcriptional responses of AB-resistant and susceptible chickpea genotypes to A. rabiei infection, identifying key pathways and hub genes involved in resistance.

Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca2+ channel function to control glucose dependent insulin secretion.

The paper shows local activation of focal adhesion kinase at the β cell capillary interface regulates presynaptic scaffold proteins and Ca2+ channel function to control glucose-dependent insulin secretion.

The nuclear effector ArPEC25 from the necrotrophic fungus Ascochyta rabiei targets the chickpea transcription factor CaβLIM1a and negatively modulates lignin biosynthesis for host susceptibility

The Ascochyta rabiei effector ArPEC25 enters the host nucleus and targets the transcription factor CaβLIM1a to manipulate phenylpropanoid pathway for negative modulation of chickpea lignin biosynthesis.

Identification and validation of E3 ubiquitin ligase XIAP as a novel substrate of deubiquitinase USP7 (HAUSP) - Implication towards oncogenesis

This study identifies XIAP as a novel substrate of USP7, showing that USP7 stabilizes XIAP to promote tumorigenesis by inhibiting apoptosis, and finds that combined inhibition of USP7 and XIAP enhances apoptosis.

The minimum land area requiring conservation attention to safeguard biodiversity

The paper estimates that 64 million km2 of terrestrial land requires conservation attention to safeguard biodiversity, with potential losses of 1.3 million km2 by 2030 under intensive land-use scenarios.

Fine-tuning the transcriptional regulatory model of adaptation response to phosphate stress in maize (Zea mays L.)

This study identifies Pi-responsive genes in maize and proposes an updated transcriptional regulatory model for Pi starvation response.

Investigation of the effect of temperature on the structure of SARS-Cov-2 Spike Protein by Molecular Dynamics Simulations

This study uses molecular dynamics simulations to investigate how temperature affects the structure of the SARS-CoV-2 Spike protein, revealing temperature-dependent conformational changes that impact its ability to bind to ACE2.

Modulation of fungal virulence through CRZ1 regulated F-BAR-dependent actin remodeling and endocytosis in chickpea infecting phytopathogen Ascochyta rabiei

This study identifies an F-BAR domain protein, ArF-BAR, in the fungus Ascochyta rabiei that regulates endocytosis and virulence in chickpea plants, with its expression controlled by the transcription factor ArCRZ1.

Transcriptomic dysregulations associated with SARS-CoV-2 infection in human nasopharyngeal and peripheral blood mononuclear cells

This study compares transcriptomic responses to SARS-CoV-2 infection in nasopharyngeal and peripheral blood mononuclear cells, identifying compartment-specific gene expression patterns and potential biomarkers.

Structural Features and Oligomeric Nature of Human Podocin Domain

This study investigates the oligomeric structure of a truncated podocin domain, showing it primarily forms a 16mer with significant secondary structure and moderate tertiary packing.

Nest records, Nest Site selection of Gyps bengalensis White-rumped Vulture and the role of Feeding Station in Kangra, Himachal Pradesh

This study records nest sites of White-rumped Vultures in Kangra, Himachal Pradesh, and finds that elevation, aspect, and proximity to feeding stations influence nesting site selection.

Human Beta Cell Mass Expansion In Vivo With A Harmine and Exendin-4 Combination: Quantification and Visualization By iDISCO+ 3D Imaging

This study shows a combination of DYRK1A inhibitor and GLP1R agonist increases human beta cell mass in vivo by 400-700% in mice, using iDISCO+ 3D imaging for quantification.

Effect of light intensity and nutritional value of food resources on flight response of adult parasitoid, Cotesia plutellae (Kurdjumov) (Hymenoptera: Braconidae)

This study examines how light intensity and feeding conditions affect the vertical flight response of adult Cotesia plutellae wasps, finding that light intensity increases female flight activity while feeding conditions influence flight behavior differently in males and females.

Rat bone marrow derived mesenchymal stem cells differentiate to germ cell like cells

This study shows rat bone marrow-derived mesenchymal stem cells can differentiate into male germ cell-like cells in vitro, offering potential for fertility research and therapeutic applications.

Network analysis of the hominin origin of Herpes Simplex virus 2 from fossil data

This paper uses network analysis to trace the evolutionary path of HSV2 from chimpanzees to humans, identifying Homo rudolfensis as the likely intermediate host.