Author

N. U. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:whole-exome sequencing· 4 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

E. P. Winer· 4 shared A. G. Waks· 3 shared N. Wagle· 3 shared O. Cohen· 3 shared D. Kim· 2 shared K. Helvie· 2 shared K. J. Kowalski· 2 shared M. R. Lloyd· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

E. P. Winer

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Author profile →

5 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 25, 2023

Structural and functional vascular dysfunction within brain metastases is linked to pembrolizumab inefficacy

A. E. Kim, K. W. Lou, A. Giobbie-Hurder…·E. R. Gerstner

This study links structural and functional vascular dysfunction in brain metastases to pembrolizumab resistance by analyzing perfusion MRI data from 44 patients.

DOI 10.1101/2023.08.25.554868

humanimaging

𝕏 PostBluesky

Cancer BiologybioRxivNov 28, 2019

The genomic landscape of intrinsic and acquired resistance to cyclin-dependent kinase 4/6 inhibitors in patients with hormone receptor positive metastatic breast cancer

S. A. Wander, O. Cohen, X. Gong…·N. Wagle

The paper identifies eight resistance mechanisms to CDK4/6 inhibitors in HR+ breast cancer, present in 80% of resistant tumors, with potential therapeutic strategies.

DOI 10.1158/2159-8290.cd-19-1390

humanwhole-exome sequencing

𝕏 PostBluesky

Cancer BiologybioRxivNov 10, 2019

Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer

A. G. Waks, O. Cohen, B. Kochupurakkal…·N. Wagle

This study identifies genomic reversion and increased DNA end resection as mechanisms of resistance to PARP inhibitors and platinum in BRCA1/2-mutant metastatic breast cancer, with RAD51 foci as a potential biomarker.

DOI 10.1016/j.annonc.2020.02.008

humanwhole-exome sequencing

𝕏 PostBluesky

Cancer BiologybioRxivOct 7, 2019

Acquired FGFR and FGF alterations confer resistance to estrogen receptor (ER) targeted therapy in ER+ metastatic breast cancer

P. Mao, O. Cohen, K. J. Kowalski…·N. Wagle

This study identifies FGFR and FGF pathway alterations as acquired resistance mechanisms to ER-targeted therapy in ER+ metastatic breast cancer and suggests targeted inhibitors as potential treatments.

DOI 10.1158/1078-0432.ccr-19-3958

humanwhole-exome sequencing

𝕏 PostBluesky

Cancer BiologybioRxivApr 21, 2019

Machine learning predicts rapid relapse of triple negative breast cancer

Y. Zhang, W. Nock, M. Wyse…·D. G. Stover

The paper uses machine learning to predict rapid relapse of triple-negative breast cancer based on clinical and genomic features.

DOI 10.1186/s12885-021-08320-7

humanbulk RNA-seq

𝕏 PostBluesky