An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication
G. Song, E. M. Lee, J. Pan, M. Xu, H.-S. Rho, Y. Cheng, N. Whitt, S. Yang, J. Kouznetsova, C. Klumpp-Thomas, S. Michael, C. Moore, K.-J. Yoon, K. Christian, A. Simeonov, , H. Zhu
The paper identifies the proteasome as critical for ZIKV and DENV replication through three systems biology approaches and finds proteasome inhibitors suppress both viruses.
bioRxiv · Mar 4, 2020Microbiology