C. Moore

Spatial proteomic analysis of a lung cancer model reveals regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses

The paper identifies regulatory T cells as mediators of resistance to KRAS-G12C inhibitors and anti-PD-1 therapy through spatial proteomic analysis of lung cancer models.

How clinically relevant are prostate cancer cell lines? A comprehensive characterisation and multiomics comparison.

This study evaluates the clinical relevance of prostate cancer cell lines by comparing them to human patient data and multiomics profiles, finding they represent a small fraction of patients and recommending a tailored selection pipeline.

Combining RASG12C(ON) inhibitor with SHP2 inhibition sensitises immune excluded lung tumours to immune checkpoint blockade: a strategy for turning cold tumours hot

This paper shows that combining RASG12C(ON) and SHP2 inhibitors can make cold lung tumors responsive to immune checkpoint blockade by altering the tumor microenvironment and enhancing anti-tumor immunity.

Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma

This study shows alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma cells, affecting genomic stability and cancer progression.

A polydiolcitrate-MoS2 composite for 3D printing Radio-opaque, Bioresorbable Vascular Scaffolds

This paper develops a polydiolcitrate-MoS2 composite for 3D printing bioresorbable vascular scaffolds that are X-ray visible and suitable for non-invasive monitoring.

Impact of whole-genome duplications on structural variant evolution in the plant genus Cochlearia

This study examines how whole-genome duplications in Cochlearia plants increase structural variant diversity and its impact on adaptation to environmental changes.

Kinetochore and ionomic adaptation to whole genome duplication

This study identifies genetic adaptations to whole genome duplication in Cochlearia species, highlighting kinetochore and ion transport gene changes across multiple WGD events.

CRISPR/Cas9 screen identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer

The paper identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer through CRISPR/Cas9 screening and shows targeting COX-2 enhances immune checkpoint blockade efficacy.

B cell repertoire of children with atopic dermatitis exhibit altered IgE maturationassociated with allergic food sensitization

The paper examines IgE B cell repertoires in children with atopic dermatitis, finding altered IgE maturation linked to allergic food sensitization and pet ownership effects.

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

This study shows lysosomal damage leads to mitochondrial proteome changes and metabolic reprogramming in macrophages, affecting immune responses to infections.

Genomic islands of divergence between Drosophila yakuba subspecies predominantly overlap with chromosomal inversions

The paper identifies genomic islands of divergence in Drosophila yakuba mayottensis linked to chromosomal inversions and metabolic adaptations to noni fruits.

A unified peptide array platform for antibody epitope binning, mapping, specificity and predictive off-target binding

This paper introduces a unified peptide array platform for high-resolution antibody epitope binning, mapping, and off-target binding prediction, demonstrating its application with anti-HER2 monoclonal antibodies.

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits comparable B cell expansion, neutralizing antibodies and protection against Omicron

This study compares B cell responses and protection against Omicron after boosting vaccinated macaques with mRNA-1273 or mRNA-Omicron vaccines, finding comparable immunity and protection.

Therapeutic KRASG12C inhibition drives effective interferon-mediated anti-tumour immunity in immunogenic lung cancers

KRASG12C inhibition enhances anti-tumour immunity in immunogenic lung cancers by upregulating interferon signaling through Myc repression, but only synergizes with immune checkpoint blockade in highly immunogenic models.

Characterisation of tumour immune microenvironment remodelling following oncogene inhibition in preclinical studies using an optimised imaging mass cytometry workflow

The paper optimises an imaging mass cytometry workflow to study TME remodelling in mouse models after KRAS G12C inhibitor treatment.

Epidermal TRPV4 ion channels regulate UVB induced sunburn by triggering inflammmasome activation and MAPK signaling

This study investigates how TRPV4 ion channels in keratinocytes mediate UVB-induced inflammation by activating inflammasomes and MAPK signaling, leading to IL-1β secretion and pain.

An immunogenic model of KRAS-mutant lung cancer for study of targeted therapy and immunotherapy combinations

This paper develops an immunogenic mouse model of KRAS-mutant lung cancer that responds to immunotherapy and reveals immune responses target endogenous retroviral antigens rather than neoantigens.

Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance

This study shows that targeted cancer therapy induces APOBEC-mediated mutagenesis, promoting drug resistance by increasing genetic diversity through mechanisms involving NF-κB activation and reduced DNA repair.

Variation in relaxation of non-photochemical quenching in a soybean nested association mapping panel as a potential source for breeding improved photosynthesis

The paper measures NPQ relaxation variation in a soybean NAM panel to assess its potential for improving photosynthesis through breeding.

Miniaturized Devices for Bioluminescence Imaging in Freely Behaving Animals

This paper demonstrates a modified fluorescent miniscope capable of detecting bioluminescence in vivo with improved sensitivity and reduced hardware complexity.

Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans

The paper identifies pre-existing and de novo humoral immunity to SARS-CoV-2 in humans, showing that uninfected individuals have SARS-CoV-2 S-reactive antibodies, particularly in children, and that infection leads to higher antibody titres targeting multiple subunits.

An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication

The paper identifies the proteasome as critical for ZIKV and DENV replication through three systems biology approaches and finds proteasome inhibitors suppress both viruses.

Epidemiology of paediatric gastrointestinal colonisation by extended spectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolates in north-west Cambodia

The paper investigates ESC-R-EC and ESC-R-KP colonization in Cambodian children, identifies risk factors, and characterizes resistance gene diversity and genetic contexts.