Cell BiologybioRxiv
Stepwise autophosphorylation regulates biased agonism of the insulin receptor
N.-O. Yunn, M. Park, J. Noh, S. H. Ryu
This study shows that stepwise autophosphorylation of the insulin receptor is regulated by symmetric insulin binding, leading to biased agonism with metabolic effects.
DOI 10.1096/fasebj.2020.34.s1.08794