J. Noh

An ancestral vaccine induces anti-Omicron antibodies by hypermutation

This study shows that repeated mRNA vaccination leads to BCR hypermutation, enabling antibodies to neutralize Omicron variants.

Existence of blood circulating immune-cell clusters (CICs) comprising antigen-presenting cells and B cells

The paper identifies circulating immune-cell clusters (CICs) composed of antigen-presenting cells and B cells in blood, showing increased frequency in COVID-19 patients.

Granger-causal inference of the lamellipodial actin regulator hierarchy by live cell imaging without perturbation

This study uses Granger-causal inference on live cell imaging data to reconstruct cause-effect relationships among actin regulators in lamellipodia without perturbation, identifying distinct activation zones and roles.

Cell cycle-independent integration of stress signals promotes Non-G1/G0 quiescence entry

The paper identifies stress pathways in yeast that lead to high-Cdk1 quiescence, showing cell cycle-independent regulation by Xbp1.

Stereotypic Neutralizing VH Clonotypes Against SARS-CoV-2 RBD in COVID-19 Patients and the Healthy Population

The paper identifies stereotypic VH clonotypes against SARS-CoV-2 RBD in patients and healthy individuals, showing their pre-existing presence in the healthy population.

DASC, a sensitive classifier for measuring discrete early stages in clathrin-mediated endocytosis

The paper introduces DASC, a method to distinguish abortive clathrin coats from clathrin-coated pits in live-cell imaging, enabling sensitive analysis of CME progression in EAP knockdown conditions.

Stepwise autophosphorylation regulates biased agonism of the insulin receptor

This study shows that stepwise autophosphorylation of the insulin receptor is regulated by symmetric insulin binding, leading to biased agonism with metabolic effects.

A unified role for membrane-cortex detachment during cell protrusion initiation

The paper shows that membrane-cortex detachment is essential for initiating both pressure-based and actin-based protrusions, challenging the Brownian ratchet model and unifying protrusion regulation.

Neogenin-1 distinguishes between myeloid-biased and balanced Hoxb5+ mouse long-term hematopoietic stem cells

This paper identifies Neogenin-1 as a marker distinguishing myeloid-biased from balanced Hoxb5+ long-term hematopoietic stem cells in mice, revealing their functional heterogeneity and hierarchical relationship.

Determination of glucosinolate contents in Brassica germplasm collections and inter- & intra-leaves distribution pattern using UPLC-MS/MS Multiple Reaction Monitoring scan mode

The paper quantifies glucosinolate (GSL) content in Brassica germplasm and examines inter- and intra-leaf distribution patterns using UPLC-MS/MS, identifying variations and potential applications in breeding.

High-throughput retrieval of physical DNA for NGS-identifiable clones in phage display library

The paper introduces a high-throughput platform, TrueRepertoire, for accurate clone identification and retrieval in phage display libraries, validated on a human hepatocyte growth factor-targeting scFv library.