Author
Spanish National Centre for Cardiovascular Research
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
Laura Sen-Martín, Ángel Fernández‐Trasancos, Miguel Ángel López-Unzu…·Jorge Alegre‐Cebollada
This study shows that myosin inhibition with mavacamten is effective in treating HCM caused by both truncating and missense variants in MYBPC3, despite different pathomechanisms.
María Rosaria Pricolo, Miguel Ángel López-Unzu, Natalia Vicente…·Jorge Alegre‐Cebollada
This study shows that inducing sarcomere disassembly in cardiomyocytes via titin cleavage does not lead to cell proliferation, suggesting additional factors are needed for cardiomyocyte division.
Agata Bak, Andra C. Dumitru, Alejandro Clemente-Manteca…·Jorge Alegre‐Cebollada
This study shows that glycation of cardiac titin increases in diabetes, leading to protein and cardiomyocyte stiffening through crosslinking advanced glycation end products.
Miguel Ángel López-Unzu, María Rosaria Pricolo, Roberto Silva‐Rojas…·Jorge Alegre‐Cebollada
This study shows that titin cleavage drives cardiomyocyte disengagement and fibrosis in heart disease, contributing to myocardial remodeling.