Cell BiologyMolecular Biology of the CellPeer-reviewed
Optogenetic stimulation of Lbc GEF-mediated Rho activity dynamics promotes cell invasion
Jessica S. Wagner, Konstantina Feller, Nicole Schrenke…·Perihan Nalbant
This study uses optogenetics to control Lbc GEF activity in melanoma cells, showing that increased Rho activity enhances contraction dynamics, spheroid expansion, and cell escape.
DOI 10.1091/mbc.e25-05-0260