Annette Paschen

This study identifies TRIP12 as a proteostasis-responsive E3 ligase that regulates protein stability and the proteostasis network under proteotoxic stress.

This paper compares the effects of USP7 inhibition and degradation in cancer cells, finding distinct phenotypic and proteomic responses.

This study uses optogenetics to control Lbc GEF activity in melanoma cells, showing that increased Rho activity enhances contraction dynamics, spheroid expansion, and cell escape.

This study identifies KDM5B's role in regulating the PRDX/TXN ROS detoxification system in melanoma DTPs, showing that PRDX inhibition increases ROS vulnerability and delays resistance to MAPK inhibition.

This study uses SILAC-based quantification to analyze how MAPK inhibitors affect the immunopeptidome in melanoma cells, identifying potential targets for immunotherapy.

Microphaser improves haplotyping in cancer samples to create a more accurate neopeptidome for neoantigen prediction.