Developmental BiologybioRxivPreprint
PIK3CA-related overgrowth spectrum (PROS) zebrafish models reveal pan-lineage developmental dysregulation
Hannah Brunsdon, Nuoya Wang, Micha Sam Brickman Raredon…·E. Elizabeth Patton
The paper develops zebrafish models of PROS to show that PIK3CA mutations cause non-cell-autonomous overgrowth through pan-lineage gene expression and communication changes.
DOI 10.64898/2025.12.03.691507