E. Elizabeth Patton

This paper optimizes a protocol for generating human gastruloids by adjusting culture conditions, improving efficiency and cost-effectiveness for studying early development.

The paper shows that loss of MITF activity in zebrafish melanocyte stem cells leads to premature expansion and novel transcriptional states during embryogenesis, with stage-specific effects on regeneration.

The paper develops zebrafish models of PROS to show that PIK3CA mutations cause non-cell-autonomous overgrowth through pan-lineage gene expression and communication changes.

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

This study identifies two prognostic lymph node subgroups in canine oral mucosal melanoma using transcriptomics, with IBA1 expression linked to improved survival.

This study shows ALDH1A3 and ACSS2 coordinate acetaldehyde-acetyl-CoA metabolism with histone acetylation in melanoma, contributing to transcriptional heterogeneity and drug resistance.

The paper identifies Tfap2b as a marker for melanocyte stem cells in zebrafish, showing their multi-fate potential and role in melanocyte regeneration.

This study shows that fgfr3 loss-of-function in zebrafish causes cranial vault defects by delaying osteoblast expansion and differentiation, with changes in the extracellular matrix.

The paper identifies Endothelin receptor Aa as a regulator of APSC quiescence in zebrafish, linking blood vessel signals to pigment cell differentiation.

The paper identifies a wound-specific notochord sheath cell subpopulation expressing Wilms Tumor 1b that forms a stopper-like structure during vertebra repair in zebrafish.