Covalent Aurora A regulation by the metabolic integrator coenzyme A
Y. Tsuchiya, D. Byrne, S. Burgess, J. Bormann, J. Bakovic, Y. Huang, A. Zhyvoloup, S. Peak-Chew, T. Tran, F. Bellany, A. Tabor, E. Chan, L. Guruprasad, O. Garifulin, V. Filonenko, , I. Gout
This study identifies a novel covalent inhibition mechanism of Aurora A kinase by coenzyme A, showing its regulation under oxidative stress and impact on meiotic spindle formation.
bioRxiv · Nov 14, 2018Biochemistry