Protein CoAlation on TXNRD2 regulates mitochondrial thioredoxin system to protect against ferroptosis
C.-C. Lin, Y.-T. Lin, S.-Y. Chen, Y. Setayeshpour, Y. Chen, D. E. Dunn, E. J. Soderblom, G. Zhang, V. Filonenko, S. Y. Jeong, S. R. Floyd, S. Hayflick, I. Gout, J.-T. A. Chi
This study identifies CoA-mediated post-translational modification of TXNRD2 as a novel mechanism regulating the mitochondrial thioredoxin system to protect against ferroptosis.
bioRxiv · May 16, 2024 · PreprintCell Biology