Application of an NMR/crystallography fragment screening platform for the assessment and rapid discovery of new HIV-CA binding fragments
S. Lang, D. A. Fletcher, A.-P. Petit, N. Luise, P. K. Fyfe, F. Zuccotto, D. Porter, A. Hope, F. Bellany, C. Kerr, C. J. MacKenzie, P. G. Wyatt, D. W. Gray
The paper uses NMR and crystallography to identify and assess new HIV-CA binding fragments, leading to the discovery of two compounds with improved binding properties.
bioRxiv · Dec 1, 2023Pharmacology & Toxicology