ImmunologybioRxiv
Selective ablation of thymic and peripheral Foxp3+ regulatory T cell development
A. Yilmazer, D. M. Zevla, R. Malmkvist…·K. Kretschmer
This study shows that peripheral Foxp3+ Treg cells can compensate for the loss of thymic Treg cells, preventing autoimmunity, but thymic Treg cells are critical for controlling beta-cell autoimmunity in type 1 diabetes.
DOI 10.3389/fimmu.2023.1298938