Boosting bactericidal immunity of a recombinant Mycobacterium smegmatis strain via zinc-dependent ribosomal proteins
S. Singh, D. Kanzin, S. Chavez, N. A. Saavedra-Avila, T. Ng, R. Lukos, O. Mayer, J. Kim, B. Chen, M. Chen, S. Porcelli, W. R. Jacobs, S. Tiwari
This study shows that IKEPLUS, a recombinant Mycobacterium smegmatis strain, provides better protection against Mtb infection than BCG in mice when grown in low zinc media.
bioRxiv · Dec 11, 2023 · PreprintMicrobiology