S. Tiwari

Discovery of free glycated amines and glycated urea as potential markers of diabetic nephropathy

The paper identifies glycated amines and glycated urea in diabetic patients' plasma as potential biomarkers for diabetic nephropathy.

Autorepression of Yeast Hsp70 co-chaperones by intramolecular interactions involving their J-domains.

The paper investigates how J-domain proteins in yeast regulate Hsp70 chaperones through intramolecular interactions, showing auto-regulatory effects that reduce ATPase cycles.

Rv0687 a Putative Short-Chain Dehydrogenase is indispensable for pathogenesis of Mycobacterium tuberculosis.

This study shows that Rv0687, a short-chain dehydrogenase in Mycobacterium tuberculosis, is essential for bacterial survival under stress and in host models, reducing pathogenicity and increasing host survival.

Boosting bactericidal immunity of a recombinant Mycobacterium smegmatis strain via zinc-dependent ribosomal proteins

This study shows that IKEPLUS, a recombinant Mycobacterium smegmatis strain, provides better protection against Mtb infection than BCG in mice when grown in low zinc media.

Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression

This paper shows that NR0B2 in myeloid cells reduces Treg expansion and tumor growth by modulating the NLRP3 inflammasome, with small molecule agonists improving ICB efficacy in breast cancer.

The Role of Binding Site Specificity in the Disaggregation of Aβ42 Fibrils through a Synthetic Paratope

This study uses molecular dynamics simulations to investigate how a synthetic paratope binds to and disrupts Aβ42 protofibrils, revealing key interactions that could inform drug development for Alzheimer's disease.

Chemical inhibition of histidine biosynthesis curtails M. tuberculosis infection

This study designs triazole inhibitors targeting M. tuberculosis's histidine biosynthesis pathway, showing efficacy against drug-resistant strains and reducing bacterial burden in infected mice.

Functional and genetic adaptations contributing to Enterococcus faecalis persistence in the female urinary tract

This study identifies genetic adaptations in Enterococcus faecalis strains isolated from the urinary tract of postmenopausal women that may contribute to their persistence in the urinary tract.

Development of a High-Throughput Minimum Inhibitory Concentration (HT-MIC) Testing Workflow

This paper develops a high-throughput MIC testing workflow using automation and Python programming, achieving 630% faster and 100% accurate results compared to conventional methods.

Call count surveys as a tool to monitor habitats occupied by Cheer Pheasants (Catreus wallichii) in Shimla, Himachal Pradesh

The paper conducts call count surveys to assess Cheer Pheasant presence in grasslands and provides an occupancy index for habitat monitoring.

Protein kinase J regulates Rv0642c expression and sensitivity to rifampicin of mycobacteria

This study investigates the role of PknJ in regulating mmaA4 expression and rifampicin sensitivity in mycobacteria during extracellular and intracellular growth.

A Fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis.

This study uses a fragment-based approach to assess the ligandability of four enzymes in the L-arginine biosynthesis pathway of M. tuberculosis, identifying potential drug targets.

Habitat patch size and tree species richness shape the bird community in urban green spaces of rapidly urbanizing region of India.

This study examines how urban green space size and tree species richness affect bird communities in urban areas of India, finding larger green spaces and higher tree diversity support greater bird richness and density.

Heterozygous deletion of SYNGAP enzymatic domains in rats causes selective learning, social and seizure phenotypes

This study creates a rat model with SYNGAP enzymatic domain deletion, showing learning, social, and seizure deficits in heterozygous animals.

Development of RNA-based assay for rapid detection of SARS-CoV-2 in clinical samples

This paper develops a rapid colorimetric assay for detecting SARS-CoV-2 RNA in clinical samples with high sensitivity and specificity.

Land Use Change Increases Wildlife Parasite Diversity in Anamalai Hills, Western Ghats, India

The paper examines how land use change and habitat fragmentation affect gastrointestinal parasite diversity in wild mammals in the Anamalai Hills, finding increased parasite diversity with plantations and livestock but no significant effect from fragmentation.