T. Ng

Loss of TLR9 expression in breast cancer tumour cells and its role in the cell cycle.

The paper shows reduced TLR9 expression in breast cancer cells and links it to decreased proliferation and activation of senescence-related factors.

Boosting bactericidal immunity of a recombinant Mycobacterium smegmatis strain via zinc-dependent ribosomal proteins

This study shows that IKEPLUS, a recombinant Mycobacterium smegmatis strain, provides better protection against Mtb infection than BCG in mice when grown in low zinc media.

Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.

CytoPb: Segmentation-free and threshold-free analysis of highly multiplexed images of biological tissue

CytoPb provides a fast, segmentation-free, and threshold-free analysis of multiplexed tissue images with results comparable to existing methods.

Perivascular macrophages collaborate to facilitate chemotherapy resistance in cancer

This study identifies Lyve-1+ perivascular macrophages that form nests and contribute to chemotherapy resistance by excluding CD8+ T-cells and relying on IL-6 and CCR5/CCL3/4 signaling.

RUNIMC: An R-based package for imaging mass cytometry data analysis and pipeline validation

The paper introduces RUNIMC, an R package for imaging mass cytometry data analysis, comparing an unbiased approach with a biased method using synthetic and clinical datasets.

Somatosensory signals from the controllers of an extra robotic finger support motor learning

This study shows that intrinsic somatosensory signals from body parts controlling a robotic device support motor learning and performance, even when artificial feedback is absent.

Macrophages orchestrate the expansion of a pro-angiogenic perivascular niche during cancer progression

This study identifies Lyve-1+ tumor-associated macrophages that support tumor growth by maintaining a pro-angiogenic perivascular niche through platelet-derived growth factor-CC-dependent expansion of mesenchymal cells.

Contrast-Enhanced, Molecular Imaging of Vascular Inflammation in the Mouse Model by Simultaneous PET/MRI

This study validates a PET/MRI insert for multimodal imaging of vascular inflammation in mice, using iron oxide nanoparticles targeting VCAM-1 to identify inflamed regions and assess plaque stability.

Evidence for a Recombinant Origin of HIV-1 group M from Genomic Variation

This study uses a sliding window approach on HIV-1/M genome sequences to detect recombination breakpoints and estimate the origin of the pandemic, finding evidence of early recombination events.