Y. Blum

p110alpha-dependent hepatocyte signaling is critical for liver gene expression and its rewiring in MASLD

This study investigates the role of p110alpha in hepatocyte signaling, showing its critical impact on liver gene expression and its rewiring in MASLD.

Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom-up approach

The paper develops an immunohistochemical panel to assess intra- and inter-tumoral heterogeneity in PDAC, identifying four distinct phenotypes with clinical implications.

Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of malignant pleural mesotheliomas to CDK4/6 inhibition

This study shows that CDK4 phosphorylation predicts sensitivity of malignant pleural mesothelioma to CDK4/6 inhibitors, with 80% of tumors expressing phosphorylated CDK4.

Crest maturation at the cardiomyocyte surface contributes to a new late postnatal development stage that controls the diastolic function of the adult heart

This study identifies a late postnatal developmental stage in rodents where cardiomyocyte surface crests mature, regulating diastolic function through ephrin-B1-dependent mechanisms.

PACpAInt: a deep learning approach to identify molecular subtypes of pancreatic adenocarcinoma on histology slides

PACpAInt uses deep learning to identify molecular subtypes of pancreatic adenocarcinoma on histology slides, revealing prognostic heterogeneity and novel subtypes.

Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival

The paper shows ERK/Akt activity waves from apoptotic cells protect neighboring cells and maintain epithelial homeostasis through EGFR and MMP signaling.

Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer

This paper develops a transcriptomic gradient (PAMG) to predict pancreatic cancer aggressiveness and treatment response using patient-derived xenografts and clinical data.