L. Lu

Generic comparison of lumen nucleation and fusion in epithelial organoids with and without hydrostatic pressure

The paper compares lumen nucleation and fusion dynamics in three epithelial organoid systems under varying hydrostatic pressure conditions, revealing conserved self-organisation rules.

AI-assisted In-silico Trial for the Optimization of Osmotherapy following Ischaemic Stroke

This paper develops an AI-assisted in-silico trial to optimize osmotherapy protocols for ischaemic stroke by predicting intracranial pressure and personalizing treatment based on patient-specific data.

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

Antigen specificity shapes antibody functions in tuberculosis.

This study shows antigen specificity shapes antibody functions in tuberculosis, with different subclasses and targets affecting disease outcomes through Fc effector mechanisms.

Targeting LxCxE cleft pocket of retinoblastoma protein in M2 macrophages inhibits ovarian cancer progression

This study shows targeting the LxCxE cleft pocket of Rb in M2 macrophages inhibits ovarian cancer progression by reducing immunosuppressive TAMs and enhancing T cell infiltration.

Improvement in Outcomes and Prevention of Multiple Organ Dysfunction Syndrome After Cardiac Arrest and Successful Cardiopulmonary Resuscitation by Systemic Administration of Bumetanide in Male Mice

This study shows that systemic bumetanide administration after cardiac arrest and CPR improves survival, reduces brain injury, and prevents multiple organ dysfunction in male mice, with LCN2/NGAL identified as a potential biomarker for early neuroprognostication.

Cloning and functional characterization of novel human neutralizing anti-interferon-alpha and anti-interferon-beta antibodies

The paper isolates and characterizes neutralizing anti-interferon-alpha and anti-interferon-beta antibodies from human patients, showing their specificity and potential therapeutic applications.

Multiple Omics Find New Cecal Microbial Features Associated with Feed Efficiency in Ducks

The paper identifies microbial and metabolic differences associated with feed efficiency in ducks using metagenomics, transcriptomics, and metabolomics.

Predicting Organoid Morphology Through a Phase Field Model: Insights into Cell Division and Lumenal Pressure

This paper uses a phase field model to predict organoid morphology by simulating cell division and lumenal pressure, identifying key parameters that determine shape and structure.

Quantitative intra-Golgi transport and organization data suggest the stable compartment nature of the Golgi

The paper challenges the classical cisternal progression model by showing that intra-Golgi transport velocity varies and Golgi residence times differ for different cargos, suggesting a stable compartment model.

A step-emulsion based digital-RPA for Pathogenic bacteria detection

This paper develops a step-emulsion microfluidic device combined with digital-RPA for rapid, sensitive, and quantitative detection of Vibrio parahaemolyticus with a detection limit of 10 CFU/L.

Unraveling the gut microbiota of Tibetan chickens: insights into highland adaptation and ecological advantages

This study compares the gut microbiota of Tibetan chickens from different environments to identify adaptations to high-altitude conditions.

De novo design of drug-binding proteins with predictable binding energy and specificity

This paper designs drug-binding proteins with low nanomolar affinity and predictable specificity using computational methods, validated by experimental measurements and structural analysis.

Study on the preparation of bovine milk exosomes and the stability of lyophilized powder

This study prepares bovine milk exosomes and evaluates the stability of their lyophilized powder, showing it can be stored at room temperature for 3 months and 2-8°C for 15 months.

Genome-wide Perturbation Analysis Screening System for Exosomes-Related Genes Based on the CRISPR/Cas9 Platform

The paper develops a CRISPR-UMI-based screening system to study exosome biogenesis, transport, and uptake mechanisms on a genome-wide scale.

UBAP2L drives scaffold assembly of nuclear pore complexes at the intact nuclear envelope

This study identifies UBAP2L's role in assembling functional nuclear pore complexes at the nuclear envelope by facilitating Y-complex formation and interactions with key nucleoporins.

miRNA-encoded regulatory peptides modulate cadmium tolerance and accumulation in rice

This study identifies miPEP156e, a miRNA-encoded peptide in rice, which enhances cadmium tolerance by modulating ROS and Cd transporter genes.

Tight junctions regulate lumen morphology via hydrostatic pressure and junctional tension

This study investigates how tight junctions regulate lumen morphology through hydrostatic pressure and junctional tension in MDCKII cysts.

A comparison of behavior paradigms assessing spatial memory in tree shrew

This study compares behavior paradigms for assessing spatial memory in tree shrews, finding the cheeseboard task most sensitive to spatial memory deficits after hippocampal lesions.

Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer

This study investigates how nutrient supply affects ASNS and GPER1 expression in KRAS mutant and wild-type colorectal cancer cells and their association with patient survival.

The novel roles of bovine milk-derived exosomes on skin anti-aging

This study investigates the effects of bovine milk-derived exosomes on human skin anti-aging, showing they enhance moisture retention and reduce wrinkles while being safe for use.

A novel purity analysis method of bovine milk-derived exosomes by two-dimensional high-performance liquid chromatography

This paper introduces a 2D-HPLC method for analyzing the purity of bovine milk-derived exosomes, showing improved accuracy, precision, and efficiency compared to existing methods.

Molecular Imaging with Fibroblast Activation Protein Tracers depicts Inflammatory Joint Damage and its Transition to Resolution of Inflammation

The paper demonstrates that fibroblast subtypes differ in FAP tracer internalization rates, enabling imaging of inflammation resolution in joints.

Polarity-driven three-dimensional spontaneous rotation of a cell doublet

This study investigates how myosin polarity drives spontaneous 3D rotation in cell doublets embedded in an extracellular matrix.

Soft multimodal opto-electric biointerfaces for co-localized optical and electrical recording of cell function

This paper introduces a flexible opto-electric device that co-locally records optical and electrical signals from cells with minimal crosstalk and high performance.

An oral vaccine for SARS-CoV-2 RBD mRNA-bovine milk-derived exosomes induces a neutralizing antibody response in vivo

An oral mRNA vaccine using bovine milk-derived exosomes encoding SARS-CoV-2 RBD induces neutralizing antibodies in mice.

West Nile Virus spread in Europe - phylogeographic pattern analysis and key drivers

This study analyzes the phylogeographic patterns of West Nile Virus in Europe, identifying key drivers like agriculture and lineage diversity.

Transparent and stretchable metal nanowire composite recording microelectrode arrays

This paper develops stretchable, transparent microelectrode arrays using gold-coated silver nanowires, demonstrating high optical transparency, low impedance, and stable performance for biomedical applications.

Analysis of sex differential genes at whole genome level reveals their organ- and chromosome-dependent expressions, regulations, and interactions

The paper analyzes sex differential genes across seven tissues in BXD mouse strains, revealing organ- and chromosome-dependent expression patterns and functional roles.

Distinguish characters of luminal and glandular epithelium from mouse uterus using a novel enzyme-based separation method

This paper introduces a novel enzyme-based method to separate luminal and glandular epithelium from mouse uterus and validates their purity and viability through transcriptome analysis and culture experiments.