Loss of allosteric regulation in α-isopropylmalate synthase identified as an antimicrobial resistance mechanism
J. R. Sullivan, C. Courtine, L. Taylor, O. Solomon, M. Behr
This paper identifies a mutation in α-isopropylmalate synthase that enables Mycobacterium abscessus to resist norvaline and epetraborole by upregulating leucine biosynthesis.
npj Antimicrobials and Resistance · Jul 3, 2023Peer-reviewedMicrobiology