M. G. Shapiro

This paper introduces a genetically encoded ultrasonic calcium reporter (URoC) for noninvasive in vivo imaging of calcium signaling in mammals.

This study investigates how the geometry of gas vesicles affects their buckling behavior under ultrasound, showing diameter has an inverse cubic effect on buckling pressure while length has minimal impact.

This paper introduces magneto-gas vesicles (MGVs) for non-invasive in vivo imaging of tissue mechanics, showing improved sensitivity and resolution compared to existing methods.

This paper presents a smart hydrogel patch for sealing and early detection of gastrointestinal anastomotic leaks using ultrasound imaging and pH/enzyme-responsive sensors.

This paper introduces Doppler Slicing, a method to achieve super-resolution ultrasound imaging of vascular structures without contrast agents by using Fourier decomposition and compressed sensing.

This study engineers AAV vectors for acoustically targeted gene delivery, improving specificity and efficiency while reducing peripheral transduction.

This paper introduces an ultrafast nonlinear ultrasound imaging technique that improves sensitivity, field of view, and frame rate for molecular and hemodynamic imaging.

The paper develops improved acoustic reporter genes for real-time in vivo tumor and therapeutic bacteria monitoring in mouse models.

The paper explains discrepancies in gas vesicle diameter measurements and provides accurate methods using electron microscopy.

This paper develops genetic circuits in T-cells that can be activated by temperature, enabling controlled immunotherapy with reduced off-target effects.

This study models shear wave propagation in the human skull caused by transcranial focused ultrasound and shows it can affect off-target structures like the cochlea.

This paper introduces genetically encoded phase contrast agents using gas vesicles for digital holographic microscopy, enabling tracking of bacteria and imaging of mammalian cell uptake.

This study demonstrates that low intensity pulsed ultrasound selectively disrupts cancer cells by exploiting their distinct mechanical properties, offering a safer alternative to high intensity ultrasound ablation.

This paper demonstrates that genetically encoded gas vesicles can be manipulated by ultrasound to control engineered cells.

This paper demonstrates the use of gas vesicles engineered to produce mechanical effects via ultrasound, enabling targeted cell lysis and therapeutic payload release in vitro, in cellulo, and in vivo.

This paper introduces gas vesicles as genetically encodable OCT contrast agents, enabling molecular and cellular imaging with OCT through differential refractive index and dynamic signal modulation.

This paper introduces mammalian acoustic reporter genes that enable ultrasound imaging of gene expression in living animals.