Microbiologynpj Antimicrobials and ResistancePeer-reviewed
Loss of allosteric regulation in α-isopropylmalate synthase identified as an antimicrobial resistance mechanism
J. R. Sullivan, C. Courtine, L. Taylor…·M. Behr
This paper identifies a mutation in α-isopropylmalate synthase that enables Mycobacterium abscessus to resist norvaline and epetraborole by upregulating leucine biosynthesis.
DOI 10.1038/s44259-023-00005-4