Cell BiologybioRxiv
Defining Substrate Requirements for Cleavage of Farnesylated Prelamin A by the Integral Membrane Zinc Metalloprotease ZMPSTE24
K. M. Wood, E. D. Spear, O. W. Mossberg…·S. Michaelis
This study identifies flexible substrate requirements for ZMPSTE24 cleavage of prelamin A using a yeast system, showing that both the C-terminal and N-terminal regions have variable length and composition needs.
DOI 10.1371/journal.pone.0239269