Author

P. A. Goloubinoff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Organism:E. coli· 1 Approach:experimental assay· 1 Organism:multiple species· 1 Research Focus:phylogenetics / evolution· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

D. S. Tawfik· 1 shared G. Schreiber· 1 shared M. Rebeaud· 1 shared O. Melanker· 1 shared S. Mallik· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 4 mutual co-author links

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1 shared paperEvolutionary Biology

D. S. Tawfik

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2 papers

Recent·Most cited

Evolutionary BiologybioRxivNov 30, 2021

In vitro evolution of uracil glycosylase towards DnaKJ and GroEL binding evolves different misfolded states

O. Melanker, P. A. Goloubinoff, G. Schreiber

This study uses in vitro evolution to select uracil glycosylase mutants binding to GroEL, DnaKJ, or E. coli extract, revealing distinct misfolded states and selection pressures.

DOI 10.1016/j.jmb.2022.167627

E. coliproteomics

𝕏 PostBluesky

Evolutionary BiologybioRxivJun 8, 2020

On the evolution of chaperones and co-chaperones and the expansion of proteomes across the Tree of Life

M. Rebeaud, S. Mallik, P. A. Goloubinoff, D. S. Tawfik

The paper analyzes proteome complexity across the Tree of Life, showing significant expansion in protein numbers, size, and fold diversity, accompanied by the evolution of chaperone systems to manage protein quality.

DOI 10.1073/pnas.2020885118

multiple speciesprotein structure

𝕏 PostBluesky