Metformin Impairs Intestinal Fructose Metabolism
W. Tong, S. A. Hannou, A. Sargsyan…·M. A. Herman
This study shows metformin reduces intestinal fructose metabolism and glucose production, along with decreased fructose delivery to the liver in mice.
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3 papers
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W. Tong, S. A. Hannou, A. Sargsyan…·M. A. Herman
This study shows metformin reduces intestinal fructose metabolism and glucose production, along with decreased fructose delivery to the liver in mice.
A. Sargsyan, L. Doridot, S. A. Hannou…·M. A. Herman
The paper identifies HGFAC as a ChREBP-regulated hepatokine that improves glucose and lipid homeostasis through activation of PPARγ in mice.
D. P. Bhatt, C. A. Mills, K. A. Anderson…·M. D. Hirschey
This study identifies glutarylation of GCDH by glutaryl-CoA and shows SIRT5 deglutarylates GCDH, restoring its function and regulating lysine metabolism in mice.